Rosmarinic acid |
| Catalog No.GN10648 |
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid has antiviral, antibacterial, antiinflammatory, neuroprotective, anticancer, anti-lipid peroxidative, apoptotic,and antioxidant activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20283-92-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid has antiviral, antibacterial, antiinflammatory, neuroprotective, anticancer, anti-lipid peroxidative, apoptotic,and antioxidant activities[1]. Rosmarinic acid has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling[2].
Rosmarinic Acid (2, 4µg/mL; 24h) Promote NHE1 Expression In Vitro[3].Rosmarinic acid (10-100µg/mL; 12h) inhibited ROS and MMP-1 production in NHDF cells induced by H2O2 and UVA, respectively, without exerted cytotoxicity; and Nitric oxide and inducible nitric oxide synthase (iNOS) productions were inhibited by Rosmarinic acid (10-100µg/mL; 12h) in RAW264.7 mouse macrophage cells induced by combined LPS-IFN-γ[4].
Rosmarinic acid (50, 100mg/kg; po, 8 weeks) mediates reverse cholesterol transport through increased plasma cholesterol uptake and subsequent hepatobiliary excretion and induces lipid metabolism by increasing fatty acid β-oxidation in AMPK-dependent activation of CPT1A, thus modulating lipid accumulation and attenuating hyperlipidemia in HFD-fed mice[5].Rosmarinic acid (100mg/kg; po; 30d) alleviates pancreatic β-cell dysfunction and glucolipotoxicity-mediated oxidative stress during HFD-STZ-induced type 2 diabetes mellitus, perhaps through its antioxidant potential[6].
References:
[1].El Kantar S, Yassin A, Nehmeh B, et al. Deciphering the therapeutical potentials of rosmarinic acid[J]. Scientific Reports, 2022, 12(1): 15489.
[2].Lee J, Jung E, Kim Y, et al. Rosmarinic acid as a downstream inhibitor of IKK‐β in TNF‐α‐induced upregulation of CCL11 and CCR3[J]. British journal of pharmacology, 2006, 148(3): 366-375.
[3]. Jung S W, Park G H, Kim E, et al. Rosmarinic acid, as an NHE1 activator, decreases skin surface pH and improves the skin barrier function[J]. International journal of molecular sciences, 2022, 23(7): 3910.
[4].Pattananandecha T, Apichai S, Julsrigival J, et al. Antioxidant activity and anti-photoaging effects on UVA-irradiated human fibroblasts of rosmarinic acid enriched extract prepared from Thunbergia laurifolia leaves[J]. Plants, 2021, 10(8): 1648.
[5]. Nyandwi J B, Ko Y S, Jin H, et al. Rosmarinic acid exhibits a lipid-lowering effect by modulating the expression of reverse cholesterol transporters and lipid metabolism in high-fat diet-fed mice[J]. Biomolecules, 2021, 11(10): 1470.
[6].Govindaraj J, Sorimuthu Pillai S. Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats[J]. Molecular and cellular biochemistry, 2015, 404: 143-159.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *