SB 215505 |
| Catalog No.GC50014 |
SB 215505는 5-HT2B, 5-HT2A, 5-HT2C에 대해 각각 pKi 값이 8.3, 6.77, 7.66인 강력한 아형 선택적 5-HT2B 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 162100-15-4
Sample solution is provided at 25 µL, 10mM.
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Potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). Increases wakefulness and motor activity in rats. Orally active.
Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID:9886683 |Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572 PMID:10188965 |Kantor et al (2004) Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. Br.J.Pharmacol. 142 1332 PMID:15265808
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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