Tarafenacin |
| Catalog No.GC13618 |
Tarafenacin(SVT-40776)은 M3 무스카린 수용체 길항제(Ki= 0.19 nM)로 M2 수용체에 비해 ~200배 선택성이 높습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 385367-47-5
Sample solution is provided at 25 µL, 10mM.
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Tarafenacin is a selective antagonist of M3 muscarinic receptor with Ki value of 0.19nM [1].
Tarafenacin is a novel quinuclidine derivative and is developed as an antimuscarinic drug for treatment of overactive bladder. It shows a 203-fold selectivity with M3 receptor over M2 receptor. Tarafenacin reduces the maximum carbachol response at concentrations of 10nM and 100nM in mouse isolated bladder. In mouse atrial preparations, tarafenacin slightly attenuates the effects on heart rate caused by carbachol. Tarafenacin shows a 199-fold urinary affinity against cardiac affinity. It is a highly potent antagonist in the bladder and lacks any relevant effect in atria at the same range of concentrations. In the guinea pig model, tarafenacin significantly changes the bladder contraction amplitude. It inhibits 25% of spontaneous bladder contractions at dose of 17.1nmol/kg [1].
References:
[1] Salcedo C, Davalillo S, Cabellos J, et al. In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. British journal of pharmacology, 2009, 156(5): 807-817.
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