TC-S 7005 |
| Catalog No.GC16771 |
TC-S 7005는 Plk2, Plk3 및 Plk1에 대해 IC50이 각각 4nM, 24nM 및 214nM인 Polo-like kinases(Plks) 억제제입니다.
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Cas No.: 1082739-92-1
Sample solution is provided at 25 µL, 10mM.
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TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].
TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates[2].
References:
[1]. Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.
[2]. Stephan Reinhard Künzel, et al. Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation. bioRxiv 445098
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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