TL 13-12 |
| Catalog No.GC50560 |
TL 13-12는 강력하고 선택적인 ALK-PROTAC 분해제이며 0.69nM의 IC50 값으로 ALK 활성을 억제합니다. TL 13-12는 또한 각각 13.5nM, 5.74nM, 18.4nM 및 65nM의 IC50 값으로 Aurora A, FER, PTK2 및 RPS6KA1을 포함한 추가 키나제의 분해를 촉진합니다. TL 13-12는 TAE684와 포말리도마이드의 Cereblon 리간드의 접합으로 구성됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229037-04-9
Sample solution is provided at 25 µL, 10mM.
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Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide , conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat.No. 6745). Maximum degradation is exhibited at 16 h. Negative control TL 13-22 also available.
Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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