>>Signaling Pathways>> Immunology/Inflammation>> Interleukin Related>>Rilonacept

Rilonacept

Catalog No.GC70300

이종 융합 단백질인 Rilonacept (Arcalyst)는 인터류킨 1억제제다.

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Rilonacept Chemical Structure

Cas No.: 501081-76-1

Size 가격 재고 수량
1 mg
US$972.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes.

Rilonacept blocks IL-1α signaling by acting as a soluble decoy receptor that binds IL-1β and prevents its interaction with cell–surface receptors, thereby reducing the inflammatory process[1].

References:
[1]. Kapur S, et, al. Rilonacept (arcalyst), an interleukin-1 trap for the treatment of cryopyrin-associated periodic syndromes. P T. 2009 Mar;34(3):138-41.

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