Roluperidone (CYR-101) (Synonyms: CYR-101; MIN-101; MT-210) |
| Catalog No.GC30206 |
롤루페리돈(CYR-101)(CYR-101)은 5-HT2A 및 시그마-2 수용체(5-HT2A 및 시그마-2에 대해 각각 7.53 nM 및 8.19 nM의 Ki)에 대해 높은 등능 친화도를 갖는 새로운 고리형 아미드 유도체입니다. .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 359625-79-9
Sample solution is provided at 25 µL, 10mM.
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Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).
Roluperidone (CYR-101) also shows binding affinity for α1-adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways, as well as in calcium neuronal modulation[1].
[1]. Davidson M, et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Jul 28:appiajp201717010122.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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