Rubiadin-1-methyl ether (Synonyms: NSC 59063, RBM) |
| Catalog No.GC60331 |
Rubiadin-1-methyl ether는 Morinda officinalis How에서 분리된 천연 안트라퀴논으로 NF-κB p65의 인산화 및 IκBα 분해 억제 및 p65의 핵전위 감소를 통해 파골세포의 골흡수를 억제한다.
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Cas No.: 7460-43-7
Sample solution is provided at 25 µL, 10mM.
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Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].
[1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.
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