(S,R,S)-AHPC (Synonyms: VH032-NH2; VHL ligand 1) |
| Catalog No.GC62283 |
(S,R,S)-AHPC(VH032-NH2)는 von Hippel-Lindau(VHL) 단백질 모집에 사용되는 VH032 기반 VHL 리간드입니다. (S,R,S)-AHPC는 링커에 의해 단백질에 대한 리간드(예: BCR-ABL1)에 연결되어 PROTAC(예: GMB-475)를 형성할 수 있습니다. GMB-475는 Ba/F3 세포에서 1.11μM의 IC50으로 BCR-ABL1의 분해를 유도합니다.
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Cas No.: 1448297-52-6
Sample solution is provided at 25 µL, 10mM.
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(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
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