SBI-477 |
| Catalog No.GC39147 |
SBI-477은 전사 인자 MondoA를 비활성화하여 인슐린 신호를 자극하는 화학적 프로브로, 인슐린 경로 억제제인 TXNIP(티오레독신 상호 작용 단백질) 및 ARRDC4(아레스틴 도메인 함유 4)의 발현을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 781628-99-7
Sample solution is provided at 25 µL, 10mM.
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SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
[1]. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.
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