SGA360 |
Catalog No.GC18821 |
SGA360은 AHR이 동족 반응 요소(부분 길항제)에 결합할 필요가 없는 기전을 통해 AHR 의존적 방식으로 염증성 SAA1 신호 전달을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 680611-86-3
Sample solution is provided at 25 µL, 10mM.
SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons. SGA360 competitively binds to AhR (IC50 = 3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema. SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed.
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Average Rating: 5
(Based on Reviews and 36 reference(s) in Google Scholar.)Review for SGA360
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