Simeprevir (sodium salt) |
| Catalog No.GC44891 |
Simeprevir(TMC435; TMC435350) 나트륨은 0.36nM의 Ki를 갖는 경구, 강력하고 고도로 특이적인 C형 간염 바이러스(HCV) NS3/4A 프로테아제 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1241946-89-3
Sample solution is provided at 25 µL, 10mM.
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Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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