SL 01 (Synonyms: NSC 251810, SL 01, Z-L-Phe Chloromethyl Ketone, ZPCK) |
| Catalog No.GC44897 |
SL 01은 개선된 경구 생체이용률을 위해 설계된 젬시타빈의 경구 활성 전구약물입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26049-94-5
Sample solution is provided at 25 µL, 10mM.
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SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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