SLF1081851 (hydrochloride) |
| Catalog No.GC91759 |
SLF1081851 is an inhibitor of sphingosine-1-phosphate (S1P) transporter (SPNS2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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SLF1081851 is an inhibitor of sphingosine-1-phosphate (S1P) transporter (SPNS2).[1] It inhibits mouse Spns2 by 67% when used at a concentration of 2 µM. SLF1081851 inhibits S1P export from HeLa cells expressing mouse Spns2 (IC50 = 1.93 µM). In vivo, SLF1081851 (20 mg/kg) decreases blood lymphocyte numbers and plasma S1P levels in mice.
References:
[1].Fritzemeier, R., Foster, D., Peralta, A., et al.Discovery of in vivo active sphingosine-1-phosphate transporter (Spns2) inhibitorsJ. Med. Chem.65(11)7656-7681(2022).
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