SLIGRL-NH2 (trifluoroacetate salt) |
| Catalog No.GC44900 |
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand. The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2). SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM), without requiring receptor cleavage. This peptide does not activate PAR1. Through its effects on PAR2, SLIGRL-NH2 stimulates gastric and intestinal smooth muscle contraction and induces thermal hyperalgesia in mice. SLIGRL-NH2 is used to explore signaling through PAR2 in cells and in animals.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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