SM-433 |
| Catalog No.GC63195 |
Smac 모방체인 SM-433은 세포자멸사 단백질(IAP) 억제제의 억제제로 작용합니다. SM-433은 IC50<1μM로 강한 결합 친화력 XIAP BIR3 단백질을 나타냅니다(특허 WO2008128171A2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1071992-81-8
Sample solution is provided at 25 µL, 10mM.
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SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].
SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].
[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.
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