Sofpironium bromide (Synonyms: BBI 4000) |
| Catalog No.GC63196 |
소피로늄 브로마이드(BBI 4000)는 원발성 겨드랑이 다한증(PAH) 연구에 사용되는 항콜린제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1628106-94-4
Sample solution is provided at 25 µL, 10mM.
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Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes[1].
Sofpironium bromide is metabolized mainly through non-enzymatic hydrolysis, and also through oxidative metabolism via CYP2D6 and CYP3A4[1].
Sofpironium bromide exhibits anticholinergic activity by inhibiting the contractile activity of guinea pig ileal tissue in a concentration-dependent manner. In a rat model, Sofpironium bromide reduces footpad sweating induced by Pilocarpine (a muscarinic receptor agonist)[1].
[1]. Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80(18):1981-1986.
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