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Solanesol

Catalog No.GC48086

Solanesol은 Solanaceous 식물에서 주로 발견되는 지방족 테르펜 알코올로 항염, 신경 보호 및 항균 활성을 나타냅니다.

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Solanesol Chemical Structure

Cas No.: 13190-97-1

Size 가격 재고 수량
1 g
US$42.00
재고 있음
5 g
US$94.00
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10 g
US$146.00
재고 있음
25 g
US$312.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Solanesol is a trisesquiterpenoid that has been found in N. tabacum and has diverse biological activities.1,2,3 It is active against E. coli, M. phlei, P. aeruginosa, and S. aureus.1 Solanesol (40 µM) increases basal heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) activities and inhibits LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells.2 It reduces escape latency in the Morris water maze and the number of slips in a beam-crossing task in a rat model of Huntington's disease induced by 3-nitropropionic acid when administered at doses of 5, 10, and 15 mg/kg.3 Solanesol is also a precursor in the formation of polynuclear aromatic hydrocarbons (PAHs), which are carcinogenic components of tobacco smoke, and has been used as a synthetic intermediate in the synthesis of coenzyme Q10 and vitamin K analogs that have antioxidant activities.1

1.Yan, N., Liu, Y., Liu, L., et al.Bioactivities and medicinal value of solanesol and its accumulation, extraction technology, and determination methodsBiomolecules9(8)334(2019) 2.Yao, X., Lu, B., LÜ, C., et al.Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cellsFood Funct.8(1)132-141(2017) 3.Mehan, S., Monga, V., Rani, M., et al.Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunctionIndian J. Pharmacol.50(6)309-319(2018)

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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