Sulfo-SMCC sodium |
| Catalog No.GC30045 |
Sulfo-SMCC 나트륨은 N-히드록시숙신이미드(NHS) 에스테르 및 말레이미드 기를 보유하고 각각 1차 아민 및 술프히드릴 기와 반응하는 일반적으로 사용되는 이종이작용성, 비절단 ADC 가교제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92921-24-9
Sample solution is provided at 25 µL, 10mM.
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Sulfo-SMCC sodium is a commonly used hetero-bifunctional crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
The crosslinker Sulfo-SMCC consists of a maleimide and an N-hydroxysuccinimide ester group to bind to sulfhydryl groups and primary amines, respectively. Sulfo-SMCC inhibits the end-to-end annealing of stabilized Microtubules (MTs). MTs are treated with 250 μM Sulfo-SMCC, and imaged after incubation for 0 h, 6 h, and 24 h. MTs treated with Sulfo-SMCC shows a constant mean length, independent of the incubation time[1].
[1]. Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11(8):e0161623.
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