Sulfosuccinimidyl Oleate (sodium salt) (Synonyms: SSO) |
Catalog No.GC44971 |
Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 μM to adipocytes.
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Cas No.: 1212012-37-7
Sample solution is provided at 25 µL, 10mM.
Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes.[1],[2] It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion.[3] SSO impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.[4]
Reference:
[1]. Harmon, C.M., Luce, P., Beth, A.H., et al. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport. J.Membrane Biol. 121, 261-268 (1991).
[2]. Abumrad, N.A., el-Maghrabi, M.R., Amri, E.Z., et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. The Journal of Biological Chemisty 268(24), 17665-17668 (1993).
[3]. Noushmehr, H., D'Amico, E., Farilla, L., et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretion. Diabetes 54(2), 472-481 (2005).
[4]. Nicholls, H.T., Kowalski, G., Kennedy, D.J., et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60(4), 1100-1110 (2011).
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