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Tafluprost ethyl amide (Synonyms: Taf EA, Tafluprost EA)

Catalog No.GC18573

Tafluprost 에틸 아미드는 프로스타글란딘 유도체입니다.

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Tafluprost ethyl amide Chemical Structure

Cas No.: 1185851-52-8

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5mg
US$189.00
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10mg
US$302.00
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Sample solution is provided at 25 µL, 10mM.

Description of Tafluprost ethyl amide

Tafluprost ethyl amide is derived from 17-phenyl trinor Prostaglandin F2α(17-phenyl trinor PGF2α). A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. As a free acid, Tafluprost is a very potent FP receptor agonist (Ki = 0.4 nM). Ethyl amides of PGs tend to increase lipid solubility, to improve uptake into tissues and to further lower the effective concentration.

Chemical Properties of Tafluprost ethyl amide

Cas No. 1185851-52-8 SDF
Synonyms Taf EA, Tafluprost EA
Chemical Name N-ethyl-9α,11α-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-amide
Canonical SMILES O[C@@H]1[C@H](C/C=C\CCCC(NCC)=O)[C@@H](/C=C/C(F)(F)COC2=CC=CC=C2)[C@H](O)C1
Formula C24H33F2NO4 M.Wt 437.5
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Tafluprost ethyl amide

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1 mg 5 mg 10 mg
1 mM 2.2857 mL 11.4286 mL 22.8571 mL
5 mM 0.4571 mL 2.2857 mL 4.5714 mL
10 mM 0.2286 mL 1.1429 mL 2.2857 mL
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In vivo Formulation Calculator (Clear solution) of Tafluprost ethyl amide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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