TAN 1364B (Synonyms: RK-682 (rac-1)) |
Catalog No.GC41443 |
RK-682의 라세미체인 TAN 1364B는 단백질 티로신 포스파타제(PTPases) 억제제입니다. TAN 1364B는 단백질 티로신 포스파타제 1B(PTP-1B), 저분자량 단백질 티로신 포스파타제(LMW-PTP) 및 세포 분열 주기 25B(CDC-25B)를 억제하며 IC50은 8.6 μ, M8,878입니다. 각각 μM.
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Cas No.: 154639-24-4
Sample solution is provided at 25 µL, 10mM.
TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
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