Tat-Gap 19 (trifluoroacetate salt) |
| Catalog No.GC91472 |
Tat-Gap 19는 connexin43 (Cx43) 헤미채널의 펩타이드 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Tat-Gap 19 is a peptide inhibitor of connexin43 (Cx43) hemichannels.1 It is composed of the HIV-1 Tat protein transduction domain linked to a nine-amino acid peptide corresponding to residues 128-136 of Cx43. Tat-Gap 19 (10 µM) inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary rat hepatocytes.2 It reduces infarct volume in a mouse model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 25 mg/kg.1 Intraperitoneal infusion of Tat-Gap 19 (1 mg/kg per day) reduces fibrotic lesion area and the area of hepatic stellate cells, precursors of myofibroblasts, expressing α-smooth muscle actin (α-SMA) in a mouse model of thioacetamide-induced liver injury.2 It increases superoxide dismutase (SOD) activity in hepatic cells isolated from the same mice.
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