TCPOBOP |
| Catalog No.GC10567 |
TCPOBOP는 간 손상이나 조직 손실 없이 강력한 간세포 증식 및 간비대를 유도하는 구성적 안드로스탄 수용체(CAR) 작용제입니다. TCPOBOP는 Bcl-2 단백질을 변경하여 Fas 유발 쥐 간 손상을 약화시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76150-91-9
Sample solution is provided at 25 µL, 10mM.
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TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].
References:
[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.
[2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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