Tempo
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| Catalog No.GC39512 |
Tempo는 전형적인 니트록사이드 라디칼이며 촉매 사이클에서 슈퍼옥사이드를 불연소화하는 ROS의 선택적 스캐빈저입니다. 템포는 DNA 가닥 파손을 유도합니다. Tempo는 1차 알코올을 알데히드로 산화시키는 유기 촉매로 사용할 수 있습니다. 템포는 돌연변이 유발 및 항산화 효과가 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2564-83-2
Sample solution is provided at 25 µL, 10mM.
Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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