Tetrahydropiperine (Synonyms: THP) |
| Catalog No.GC40258 |
피페린의 시클로헥실 유사체인 테트라히드로피페린은 파이퍼 롱검의 최초 천연 아릴 펜탄아미드입니다. 테트라히드로피페린(화합물 14)은 시토크롬 P450(CYP) 동형 CYP1A1/아릴탄화수소 수산화효소(AHH; IC50=23 μM)를 억제합니다.
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Cas No.: 23434-88-0
Sample solution is provided at 25 µL, 10mM.
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Tetrahydropiperine is a derivative of piperine and an arylpentanamide originally isolated from P. longum that has diverse biological activities. It is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 µM). It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 µM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 µM) in rat liver microsomes. Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR). Formulations containing tetrahydropiperine have been used to increase bioavailability of compounds applied to the skin.
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