TH1338 |
| Catalog No.GC62474 |
TH1338(화합물 3b), 경구 활성 캄토테신 유도체 및 암에 대한 강력한 화학요법제는 시험관 내에서 인간 종양 세포주에 대해 우수한 세포독성 효능을 나타냅니다. TH1338(화합물 3b)은 상당한 뇌 침투, 유리한 유출 펌프 특성 및 혈액학적 독성 프로파일을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1258494-60-8
Sample solution is provided at 25 µL, 10mM.
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TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2].
TH1338 (compound 3b) demonstrates significant brain penetration when dosed orally in mice[1].TH1338 (compound 3b) exhibits potent anti-tumor activity in H460 (NSCLC) human tumor xenograft model[1].
[1]. Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23.
[2]. Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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