Thalidomide-5,6-F |
| Catalog No.GC63392 |
탈리도마이드-5,6-F는 CRBN 단백질 모집에 사용되는 탈리도마이드 기반 세레블론 리간드입니다. 탈리도마이드-5,6-F는 링커에 의해 단백질에 대한 리간드에 연결되어 PROTAC를 형성할 수 있습니다.
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Cas No.: 1496997-41-1
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763.
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