Thio-TEPA (Synonyms: NCI C01649, NSC 6396, Triethylenethiophosphoramide) |
Catalog No.GC16158 |
Thio-TEPA는 항종양 활성이 있는 DNA 알킬화제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 52-24-4
Sample solution is provided at 25 µL, 10mM.
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM[1].
Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice[2].
References:
[1]. Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28(6):441-7.
[2]. Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21(4):327-30.
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