TL 13-112 |
| Catalog No.GC50561 |
TL 13-112는 강력하고 선택적인 ALK-PROTAC 분해제이며 0.14nM의 IC50 값으로 ALK 활성을 억제합니다. TL 13-112는 또한 각각 8550 nM, 42.4 nM, 25.4 nM 및 677 nM의 IC50 값으로 Aurora A, FER, PTK2 및 RPS6KA1을 포함한 추가 키나제의 분해를 촉진합니다. TL 13-112는 Ceritinib과 포말리도마이드의 Cereblon 리간드의 접합으로 구성됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229037-19-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. Negative control TL 13-110 also available.
Powell et al (2019) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *