>>Tominersen sodium

Tominersen sodium

Catalog No.GC70669

Tominersen sodium은 2세대 2′-O-(2-메티옥시에틸) 반의인 과뉴클레오티드로 헌팅턴 단백질(HTT) mRNA를 표적하고 HTT 생성을 효과적으로 억제한다.

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Tominersen sodium Chemical Structure

Size 가격 재고 수량
1 mg
US$221.00
재고 있음
5 mg
US$643.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD).

References:
[1]. Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74(6):1031-44.
[2]. Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380(24):2307-2316.

리뷰

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