Tos-PEG4-t-butyl ester |
| Catalog No.GC38867 |
Tos-PEG4-t-부틸 에스테르(Tos-PEG4-Boc)는 PEG 조성을 나타내는 PROTAC 링커입니다. Tos-PEG4-t-부틸 에스테르(Tos-PEG4-Boc)는 BI-3663과 같은 일련의 PROTAC 합성에 사용할 수 있습니다. BI-3663은 PTK2 분해를 위해 E3 리가아제를 가로채는 세레블론 리간드가 있는 고도로 선택적인 PTK2/FAK PROTAC이며 18nM의 IC50으로 PTK2를 억제합니다.
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Cas No.: 217817-01-1
Sample solution is provided at 25 µL, 10mM.
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Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 . BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
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