Tovetumab (Synonyms: MEDI-575) |
Catalog No.GC66385 |
토베투맙(MEDI-575)은 항-PDGFRα이고; 821d96072c2d58d8970e76f526b0f6b8PDGFRα를 선택적으로 차단하는 단클론 항체; 821d96072c2d58d8970e76f526b0f6b8신호 변환. 토베투맙은 교모세포종 및 비소세포폐암(NSCLC) 연구에 사용될 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 1243266-04-7
Sample solution is provided at 25 µL, 10mM.
Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC)[1][2].
Tovetumab (10-100 nM, 1-2 h) binds to PDGFRα on H1703 cells (determined by Alexa647-labeled tovetumab)[1].
Tovetumab (0.001-10 nM, 10 min) inhibits ligand-induced phosphorylation of human PDGFRα in MG-63 cells[2].
Tovetumab (0.001-100 nM, 72 h ) inhibits Ligand-induced proliferation of cancer-associated fibroblasts (CAFs) [2].
Tovetumab (0.6-60 mg/kg, i.v.) blocks the PDGFRα-mediated elimination of PDGF-AA, leading to an increase in circulating PDGF-AA level in Cynomolgus monkeys[1].
Tovetumab (10 mg/kg, i.p., twice a week) inhibits tumor growth in U118 glioma xenografts[2].
Animal Model: | Cynomolgus monkey[1] |
Dosage: | 0.6, 6.0, and 60 mg/kg |
Administration: | Intravenous injection (i.v.) |
Result: | Induced > 100- fold increases in circulating concentrations of PDGF-AA. |
Animal Model: | U118 glioma xenografts (CB17 SCID)[2] |
Dosage: | 10 mg/kg |
Administration: | Intraperitoneal injection (i.p.), twice per week. |
Result: | Produced 101% inhibition of tumor growth. |
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