Tromantadine hydrochloride |
| Catalog No.GC60373 |
항헤르페스 활성을 갖는 Amantadine 유도체인 Tromantadine 염산염은 단순 포진 바이러스 1형(HSV-1) 및 HSV-2 복제를 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41544-24-5
Sample solution is provided at 25 µL, 10mM.
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Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].
Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection[1].
[1]. Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.
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