Tubastatin A (trifluoroacetate salt) |
| Catalog No.GC45095 |
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.
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Cas No.: 1239262-52-2
Sample solution is provided at 25 µL, 10mM.
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Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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