TUG-2208 |
| Catalog No.GC71501 |
TUG-2208 (화합물 42a)는 GPR84 agonist (pEC50=8.98)로 lipophilicity 가 낮고 용해도, in vitro 투과성 및 microsomal 안정성이 우수하다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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TUG-2208 (0.1; 1 mM 4; 96 h) shows excellent stability in mouse liver microsomes[1].
TUG-2208 (10 μM) exhibits over 1000-fold selectivity for GPR84 compared to other free fatty acid receptors (FFA1, FFA2, FFA3, FFA4)[1].
References:
[1]. Ieremias L, et al., Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists. J Med Chem. 2024 Feb 21.
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