Tuspetinib (Synonyms: HM43239) |
| Catalog No.GC69233 |
Tuspetinib (HM43239)은 경구용 활성화된 선택적 FLT3 억제제로, IC50 값은 1.1 nM (FLT3 와일드 타입), 1.8 nM (FLT3 ITD 돌연변이형) 및 1.0 nM (FLT3 D835Y 돌연변이형)입니다. Tuspetinib는 가역적인 I 유형 억제제로 직접적으로 FLT3의 키나아제 활성을 억제하며, p-STAT5, p-ERK SYK, JAK1/2 및 TAK1을 조절합니다. Tuspetinib는 백혈병 세포의 증식을 억제하고 세포 자살(apoptosis)를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2294874-49-8
Sample solution is provided at 25 µL, 10mM.
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Review for Tuspetinib
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Tuspetinib
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