Tyrothricin |
Catalog No.GC18414 |
티로트리신은 바실러스 브레비스(Bacillus brevis)에서 분리된 폴리펩타이드 항생제 혼합물이며 티로시딘(tyrocidine)과 그라미시딘(gramicidin)으로 구성됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1404-88-2
Sample solution is provided at 25 µL, 10mM.
Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.[1] [2]Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica. Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections. [1][2]
Reference:
[1]. Dubos, R.J., and Hotchkiss, R.D. The production of bactericidal substances by aerobic sporulating bacilli. J. Exp. Med. 73(5), 629-640 (1941).
[2]. Lask, S.A. Tyrothricin as an antibiotic. Arch. Surg. 56(4), 475-483 (1948).
Average Rating: 5
(Based on Reviews and 23 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *