Umirolimus |
| Catalog No.GC45114 |
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Cas No.: 851536-75-9
Sample solution is provided at 25 µL, 10mM.
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Umirolimus is a semi-synthetic macrocyclic lactone and a derivative of rapamycin that has immunosuppressive and anti-inflammatory effects. It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model, coronary stents containing umirolimus for localized delivery to the vessel wall reduced stenosis by 50% and led to less thickening of the vessel wall than a bare metal stent. Rapamycin, and likely its derivatives, binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Formulations containing umirolimus have been used in coronary stents for localized delivery to the vessel wall.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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