UT-B-IN-1 |
Catalog No.GC70608 |
UT-B-IN-1 (UTBINH-14) 는 가역적이고 경쟁적이며 선택적인 요소 트랜스퍼 단백질-B (UT-B) 억제제로서 사람과 생쥐 UT-B에 대한 IC50 값은 각각 10과 25nM이다.
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Cas No.: 892742-76-6
Sample solution is provided at 25 µL, 10mM.
UT-B-IN-1 (1-1000 nM) inhibits urea efflux in erythrocytes preloaded with urea with an IC50 value of 26.7 nM[1].
UT-B-IN-1 inhibits water transport in AQP1-null erythrocytes[1].
UT-B-IN-1 (0-10 μM;24 h) shows no cytotoxicity to MDCK cells[1].
UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1].
References:
[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.
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