UT-B-IN-1 |
| Catalog No.GC70608 |
UT-B-IN-1 (UTBINH-14) 는 가역적이고 경쟁적이며 선택적인 요소 트랜스퍼 단백질-B (UT-B) 억제제로서 사람과 생쥐 UT-B에 대한 IC50 값은 각각 10과 25nM이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 892742-76-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
UT-B-IN-1 (1-1000 nM) inhibits urea efflux in erythrocytes preloaded with urea with an IC50 value of 26.7 nM[1].
UT-B-IN-1 inhibits water transport in AQP1-null erythrocytes[1].
UT-B-IN-1 (0-10 μM;24 h) shows no cytotoxicity to MDCK cells[1].
UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1].
References:
[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *