vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus] (Synonyms: H2N-His-Leu-Ser-Leu-Leu-Thr-Thr-Leu-Ser-Asn-Arg-OH ) |
| Catalog No.GP10019 |
vitamin D binding protein precrusor
Products are for research use only. Not for human use. We do not sell to patients.
![vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus] Chemical Structure](/media/struct/GP1/GP10019.png "vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus] Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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Vitamin D-binding protein (DBP) is a multifunctional, highly expressed, polymorphic serum protein[1][2]. Since its identification in 1959, many important functions of Vitamin D binding protein have been discovered. These range from the transport of vitamin D metabolites to possible roles in the immune system and host defense[3]. The molecular weight range, time course of appearance, and effect of dietary strontium all suggested that the newly appearing protein( band C) might represent the calcium binding protein formed in response to vitamin D. Using chromatographically purified calcium binding protein from rat intestine, it was shown that this protein(band C) most probably is the calcium binding protein. The major contaminating protein in the final purification of rat calcium binding protein has also been identified on gels as the preexisting protein (band A), which is probably the precursor of the calcium binding protein.[4].
References:
[1] N.E. Cooke, J.G. Haddad, Vitamin D binding protein (Gc-globulin), Endocr. Rev., 10 (1989), pp. 294-307
[2] N.E. Cooke, J.G. Haddad, Vitamin D binding protein (Gc-globulin): update 1995, A. Negro-Vilar, D.D. Bikle (Eds.), Endocrine Reviews Monographs: 4. Hormonal Regulation of Bone Mineral Metabolism, The Endocrine Society (1995), pp. 125-128
[3] Peter White, Nancy Cooke, pThe Multifunctional Properties and Characteristics of Vitamin D-binding Proteinq,Volume 11, Issue 8, 1 October 2000, Pages 320-327.
[4] H. F. DeLuca , D. Drescher, Possible precursor of vitamin D-stimulated calcium binding protein in rats, Biochemistry, 1971, 10 (12), pp 2308-2312 , DOI: 10.1021/bi00788a020, Publication Date: June 1971.
| Cas No. | SDF | ||
| Synonyms | H2N-His-Leu-Ser-Leu-Leu-Thr-Thr-Leu-Ser-Asn-Arg-OH | ||
| Canonical SMILES | NC(CC1=CN=CN1)C(NC(CC(C)C)C(NC(CO)C(NC(CC(C)C)C(NC(CC(C)C)C(NC(C(C)O)C(NC(C(NC(CC(C)C)C(NC(CO)C(NC(CC(N)=O)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)C(O)C)=O)=O)=O)=O)=O)=O | ||
| Formula | C54H95N17O17 | M.Wt | 1254.44 |
| Solubility | ≥125.4mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.7972 mL | 3.9858 mL | 7.9717 mL |
| 5 mM | 0.1594 mL | 0.7972 mL | 1.5943 mL |
| 10 mM | 0.0797 mL | 0.3986 mL | 0.7972 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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