>>Signaling Pathways>> Proteases>> Endogenous Metabolite>>Vitamin D3

Vitamin D3 (Synonyms: Cholecalciferol, NSC 375571)

Catalog No.GC10667

비타민 D3(콜레칼시페롤, 콜레칼시페롤)는 자연적으로 발생하는 비타민 D의 형태입니다.

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Vitamin D3 Chemical Structure

Cas No.: 67-97-0

Size 가격 재고 수량
5g
US$57.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

References:
[1]. Leibowitz SB, Kantoff PW. Differentiating agents and the treatment of prostate cancer: Vitamin D3 and peroxisome proliferator-activated receptor gamma ligands. Semin Oncol. 2003 Oct;30(5):698-708.
[2]. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011 Oct;134(2):123-39. doi: 10.1111/j.1365-2567.2011.03482.x.
[3]. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36. doi: 10.1146/annurev-pharmtox-010510-100611.
[4]. Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis. 2012 Jul;60(1):139-56. doi: 10.1053/j.ajkd.2011.12.035.

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