VRK-IN-1 |
| Catalog No.GC63255 |
VRK-IN-1은 IC50이 150nM인 우두 관련 키나제 1(VRK1)의 강력하고 선택적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378855-09-3
Sample solution is provided at 25 µL, 10mM.
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VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].
VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1].VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].
[1]. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.
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