VU0364289 |
| Catalog No.GC70503 |
VU0364289 는 매우 선택적인 mGlu5 양의 변형 조절제 (PAM) (MPEP 비트와 결합) 이며 EC50은 1.6 µM입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1242443-29-3
Sample solution is provided at 25 µL, 10mM.
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VU0364289 (10, 30, 56.6, 100 mg/kg ; i.p.; once) reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, and (56.6, 100 mg/kg) shows significantly fewer ambulations[1].
VU0364289 (10 mg/kg; i.p.; once) is rapidly and significantly absorbed in rats, and shows excellent central nervous system penetration[1].
References:
[1]. Gregory KJ, et al. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther. 2013 Nov;347(2):438-57.
[2]. Ya Zhou, et al. Discovery of N-Aryl Piperazines as Selective mGluR5Potentiators with Improved In Vivo Utility. ACS medicinal chemistry letters, 2010, 1(8): 433-438.
[3]. Psychosis Models[M]//Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi, 2016: 731-750.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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