VU0420373 |
| Catalog No.GC64057 |
VU0420373은 EC50이 10.7μM이고 pEC50이 4.97인 강력한 헴 센서 시스템(HssRS) 활성제입니다.
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Cas No.: 38376-29-3
Sample solution is provided at 25 µL, 10mM.
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VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].
VU0420373 (compound 2e) has an IC50 of >60 μMfor Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1].
[1]. Brendan F Dutter, et al. Decoupling Activation of Heme Biosynthesis From Anaerobic Toxicity in a Molecule Active in Staphylococcus Aureus. ACS Chem Biol. 2016 May 20;11(5):1354-61.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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