XEN723 |
| Catalog No.GC31521 |
XEN723은 마우스와 HepG2 세포에서 각각 IC50이 45nM 및 524nM인 Stearoyl-CoA Desaturase(SCD1)의 새롭고 강력한 티아졸릴이미다졸리디논 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1072803-08-7
Sample solution is provided at 25 µL, 10mM.
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XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].
[1]. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.
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