XY028-133 |
| Catalog No.GC62701 |
XY028-133(실시예 14)은 von Hippel-Lindau 및 CDK에 대한 리간드로 구성된 항종양 활성을 갖는 PROTAC 기반 CDK4/6 분해제입니다.
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Cas No.: 2229974-73-4
Sample solution is provided at 25 µL, 10mM.
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XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1].
XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].
[1]. JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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