yGsy2p-IN-H23 |
| Catalog No.GC61406 |
yGsy2p-IN-H23은 인간 글리코겐 합성효소 1(hGYS1)에 대한 IC50이 875μM인 효모 글리코겐 합성효소 2(yGsy2p)에 대한 강력한 최초의 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1269190-98-8
Sample solution is provided at 25 µL, 10mM.
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yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs)[1].
yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].
[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.
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