>>Signaling Pathways>> Microbiology & Virology>> SARS-CoV>>Z-L(D-Val)G-CHN2

Z-L(D-Val)G-CHN2

Catalog No.GC70285

Z-L(D-Val)G-CHN2는 Z-LVG-CHN2의 동형기이다.

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Z-L(D-Val)G-CHN2 Chemical Structure

Size 가격 재고 수량
5 mg
US$167.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 . Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.

References:
[1]. R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215(1):164-71.
[2]. L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol
[3]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016.

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