L-Azidohomoalanine hydrochloride |
| Catalog No.GC50512 |
Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 942518-29-8
Sample solution is provided at 25 µL, 10mM.
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Unnatural amino acid. Incorporated into proteins during de novo protein synthesis, with no effect on protein degradation. Requires methionine-free medium for efficient incorporation. Substrate for wild-type methionyl-tRNA synthetase (MetRS) in vivo. Can be used in BONCAT (bio-orthogonal non-canonical amino acid tagging) for the identification of newly synthesized proteins.
Dieterich et al (2006) Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc.Natl.Acad.Sci.U.S.A. 103 9482 PMID:16769897 |Lang & Chin et al (2014) Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem.Rev. 114 4764 PMID:24655057 |Wang et al (2017) Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat.Protoc. 12 279 PMID:28079880
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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